Can we cure at least one autoimmune disease in humans by 2028?
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Research into CAR-T cell treatment and other genetic therapies may pave the way for cures to currently incurable autoimmune diseases. Will we be able to successfully cure a human being of an autoimmune disease in a medical trial by the end of 2028?

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Resolves to YES if, by the end of 2028, at least one human being has been cured of a currently incurable autoimmune disease. Otherwise, resolves to NO.

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I feel this may not be a valid question given the use of stem cell transplant is already being used in autoimmune diseases (eg systemic sclerosis). Many regard a successful transplant as cure.

there are many autoimmune disorders that are acute, and can show either spontaneous recovery or recovery after treatment, the problem is that we do not know how to treat those conditions that show progression despite treatment :) i would argue YES ALREADY... examples - gullain barre syndrome, that in some patients might show relapse (less than 10%), while in some others, it shows only as one episode, and then the patient is good for life... there are many conditions that have achieved total long lasting remission of the disease in patients with autologous bone marrow transplantation etc...

Clarifying the threshold for "cure" would be helpful (e.g. if I need to take meds daily and can still get occasional episodes of disease related problems, but can live mostly normal life, is that "cured"?)

@MartinModrak I would define management via daily meds and the possibility for episodes of disease as "remission", while defining a "cure" as the body being completely free of the disease without further need for intervention. There are currently autoimmune diseases, such as autoimmune thyroiditis, that are managed via daily medications with occasional disease related problems, and I would not consider these to be curable conditions.

I think a concise threshold would be "a doctor no longer considers the individual to have the disease and there is little to no chance of the disease returning."

@roughlyhewn you can pose the question, but the definitions are given by the medical community ...