As formulated, the question seems straightforwardly true because everything has some atypical ways and near-everything influences near-everything. What magnitude of effects would be sufficient for this to resolve YES?

@b575 Yeah I expect this should be a Yes, based on what we know now and it would surprise me if it wasn't. If science says any genetic makeups (including mutations) cause atypical metabolization and it influences CHS in anyway, this resolves Yes.

There are some people who don't get effects from edibles due to a liver enzyme mutation. Does the market title only refer to the linked CHS paper?

@EstMtz Yeah this is about CHS. I changed the title