Does an overstimulation of the endocannabinoid system cause a downregulation of cannabinoid receptors? | Manifold

Does an overstimulation of the endocannabinoid system cause a downregulation of cannabinoid receptors?

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https://manifold.markets/news/cannabinoid-hyperemesis-syndrome

It's possible this could contribute to CHS. The body's other systems handle overstimulation by reducing receptors or their sensitivity. If this is proven for the endocannabinoid system and it's receptors this market resolves Yes.

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Isn't this how tolerance works for any tolerance-forming drug?

@SaviorofPlant Yeah I expect this to resolve Yes, just a question of how long till it's medical fact for the endocannabinoid system.

@KeenenW Moving it to schedule 3 would probably accelerate that research...

@SaviorofPlant 100%, should accelerate our understanding of CHS as well

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